A new study has investigated the role of Krt17 in the carcinogenesis and the progression of gastric cancer (GC).
Krt17 is a 48kDa protein member of keratin family. Previous literatures have demonstrated Krt17 may play a promotive role in the progression of various malignancies. However, the exact function of Krt17 in the carcinogenesis and the progression of gastric cancer (GC) remains unknown.
A study led by Dr. Gang Zhao at the Shanghai Jiao Tong University School of Medicine detected the expression of Krt17 in 20 GC and matched normal tissues. Krt17 was found to be significantly increased in GC tissues compared to normal tissues. Immunochemistry analysis of Krt17 expression in 569 GC tissue specimens showed that the expression of Krt17 was remarkably positively correlated with the tumour size, depth of invasion, lymph node metastasis, tumour node metastasis stage and vascular invasion. High expression of Krt17 predicted a poor prognosis of GC patients. In addition, silencing of Krt17 inhibited GC cell proliferation, migration and invasion, and induced cell apoptosis by altering Bcl2 family protein expression and cleaved caspase3 upregulation. Moreover, silencing of Krt17 led to cell cycle arrest at G1/S stage by decreasing cyclin E1 and cyclin D expression.
The results from this study suggested that Krt17 can be used as a novel predictive biomarker, thus providing a novel therapeutic target for GC patients.