Researchers have explored the mechanism by which SULT1E1 influences breast cancer.
Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Breast cancer is cancer that forms in the cells of the breasts. After skin cancer, breast cancer is the most common cancer diagnosed in women in the United States. Breast cancer can occur in both men and women, but it’s far more common in women. Previous studies has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood.
A study led by Dr. Yali Xu at the Shandong University explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Researchers found that over expression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Enforced expression of SULT1E1 suppressed tumour cell migration and invasion. Moreover, the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. They also observed that the over expression of SULT1E1 significantly inhibited tumour growth in vivo.
The findings from this study suggest that SULT1E1 performed its tumour suppressor characteristics by activating PPARγ, which provides a novel target for patients with breast cancer.