TPPP3 found to promote colorectal cancer progression

A new study has suggested that tubulin polymerization promoting protein family member 3 plays an important role in colorectal cancer progress and might serve as novel therapeutic target for treatment.

Colorectal cancer (CRC) is one of the most common types of malignant tumour and the third leading cause of cancer-related deaths in the world. A growing number of studies have demonstrated that complicated pathogenesis of CRC was a multi-step process involving the deregulation of multiple oncogenes and tumour suppressors. Tubulin Polymerization Promoting Protein Family Member 3 (TPPP3), a member of the TPPP protein family, has been shown to play an important role in the initiation and progression of human cancers. However, the expression and underlying function of TPPP3 in CRC have not yet been fully clarified.

Researchers at the Fudan University in China have assessed whether TPPP3 plays any role in tumour development and progress in CRC. The results published in the Journal of Cancer show that TPPP3 is significantly increased in CRC tissues and is associated with aggressive factors and poor patient survival. Furthermore, TPPP3 knockdown inhibited CRC cell proliferation, migration, and invasion in vitro. These results suggest that TPPP3 might be a potential therapeutic target for CRC patients in future.

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