5 Best Anti-Anxiety Supplements of 2023

Which one works best for long-lasting relief of anxiousness… and for keeping a peaceful state of calm every day?

Imagine jumping out of bed every day, feeling energized and totally relaxed at the same time. 

And imagine as you go through the day, you have no anxious moments.  You’re able to breathe freely and never feel that rising, constricting tension… Never feeling like someone is stepping on your chest.

When the evening comes, you’re not worried about having sleep problems. You don’t reach for magnesium or another sleep aid to try to prevent your mind from racing. You just sleep like a baby.  Every night.

Now, imagine that all of the things you’ve probably tried… eating clean, meditating, cutting out alcohol and caffeine… none of those are necessary any more.

Well, if you’re like the thousands of others who’ve discovered the right anti-anxiety supplement, you no longer have to imagine.

People just like you now enjoy the peace and tranquility that comes with freeing yourself from anxiety.  But again, it all comes down to the right supplement.

What do I mean by the “right” anti-anxiety supplement?  Well, you see, they’re not all created equally.

Some are great, while others hardly work at all.  But they’re so important to people who suffer from anxiety and just want their life back…

How do you know the difference between the junk supplements and the ones that really work?

Most people don’t.

That’s why we did the work for you.  We set out to find the best 5 supplements for anxiety in 2023.  We analyzed hundreds of so-called anti-anxiety supplements.

Many were garbage and gave no help at all.  Perhaps a dozen worked as advertised – they promoted relaxation and a bright, positive outlook.  

And of those frontrunners, 5 rose to the top as the best of the best.  We’re going to break down those 5 here.

Before we do though, let’s look at…

How NOT to Choose an Anti-Anxiety Supplement

So many people jump on Amazon, find a supplement, and check out the reviews.  Then they order the one with the most 5-stars.

But there’s a BIG problem with this.  Many of these companies – especially the offshore ones – pay people for those reviews.  So, you never really know if the reviews you’re reading are genuine.

And as a result, people order these supplements only to be disappointed when they don’t work.  Which is a shame because the right supplement can do wonders to ease anxiety.

Benefits of a Great Anti-Anxiety Supplement

When you find the right anti-anxiety supplement, you’ll find it…

Improves mood

Boosts mental performance

Supports cognitive function

Helps to wake up feeling refreshed

Increases energy and vitality

Plant-based ingredients

When your mood is stable and you’re thinking clearly, anxiety can be a thing of the past.  So, where do you get a great anti-anxiety supplement?

It all starts with the right manufacturer…

What to Look For in a Supplement Company

When you’re choosing an anti-anxiety supplement, look for products that…

Are made right here in America

So many supplement products are cheap knock offs from overseas. Often, you don’t even get what’s listed on the label. The rule is: Make sure any supplement you buy is made in America.

Are doctor-formulated

Today’s leading doctors know that nutrition should be the first line of defense. And pills should be a last resort. Now, many of these doctors consult on supplement formulations. It’s critical you choose a doctor-formulated supplement. After all, it’s not doctor-formulated then who’s deciding what ingredients are in it? And at what dosage?

Are backed by a strong guarantee

Even the best supplements don’t work for 100% of the people. So, the supplement company you’re buying from should be confident enough in their products to offer a strong no-questions-asked guarantee. Choose products from companies with at least a 30-day money back guarantee. And preferably, a 90-day guarantee.

Have the right ingredients in the right dosage

First, you have to take the right ingredients to get the desired effects. This is normal. But most don’t realize you also have to be sure the products have the right dosage of each ingredient. Even the best ingredients won’t help you if they’re only giving half the recommended dosage. This is critical since a lot of supplement companies put profits over effectiveness.

Now that you know what to look for in a supplement company, let’s look at what ingredients to look for in a specific supplement.

What Nutrients Work Best for Anti-Anxiety?

Again, let’s look at what ingredients you DON’T want in a supplement first.

Those are…

Refined Sugars

We all know what happens after a sugar crash. A little sugar is ok, but you don’t want a supplement filled with the stuff because you’ll be doing more harm than good.

Fruit Powder

High in refined sugar, and can cause your blood sugar to spike.


They are damaging and add no value. So, why have them?


Similar to sugar. It’s ok to have some. But get yours from your favorite caffeine drink, not from your supplement.

Food Additives

These are neurotoxins that can cause your neurons to go into breakdown

Gluten, Soy, and Other Fillers

These are only used to make the supplement look more complete. Often, they can’t even be digested by our stomachs. The result is that the ingredients that do help are in too small of a dose to be effective.

Now, here’s a list of the top ingredients that DO help with anti-anxiety…



Rhodiola rosea is a perennial flowering plant in the family Crassulaceae. It grows naturally in wild Arctic regions of Europe, Asia, and North America


Ashwagandha is an evergreen shrub that grows in Asia and Africa. … Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system.


Lemon balm is a perennial herbaceous plant in the mint family and native to south-central Europe, the Mediterranean Basin, Iran, and Central Asia, but now naturalized elsewhere.


Magnolia grandiflora, commonly known as the southern magnolia or bull bay, is a tree of the family Magnoliaceae native to the southeastern United States, from Virginia to central Florida, and west to East Texas.


Theanine, also known as L-γ-glutamylethylamide and N⁵-ethyl-L-glutamine, is an amino acid analogue of the proteinogenic amino acids L-glutamate and L-glutamine and is found primarily in particular plant and fungal species.


Lutein is a xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants, and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots.

What’s the Bottom Line

When ranking the anti-anxiety supplements below, we looked for companies that met all the criteria above… with products that have all the right ingredients, in the right doses… and that have REAL 5-star reviews from happy customers.

And when we boiled all that down, these are the top 5 anti-anxiety supplements on the market in 2023…

Top 5 Sleep Supplements


by Regen Health



Overall Grade


  • Non-habit forming
  • Induces sleep quickly
  • Helps to stay asleep longer
  • Helps to wake up feeling refreshed
  • 100% natural ingredients
  • Increases energy and vitality
  • Plant-based ingredients


  • Individual results may vary

Why we choose it

We love CALM by Regen Health. It’s safe, all-natural, and powerful. It’s got an awesome blend of herbal extracts and ingredients that customers say reduces their anxiety and stress. It’s seen to decrease the amount of panic attacks. Even better, CALM has no known side effects. But, if for whatever reason you’re unhappy with your CALM, they have a 60-day refund policy. CALM was an easy #1 for us

Mood Boost

by LES Labs



Overall Grade


  • An herbal sleep supplement
  • Allergy-friendly ingredients
  • Helps with falling asleep faster
  • Promotes healthy sleep state
  • Promotes relaxation
  • Lifetime guarantee


  • May take hours to work
  • May cause grogginess
  • May cause side effects

Why we choose it

LES Labs Mood Boost is an all-natural, vegetarian formulation of herbal extracts. It’s even got L-Tyrosine and L-Theanine, which are great for reducing anxiety and help you focus. The only thing worrying about Mood Boost is the side effects. LES Labs reported some like mood swings, irritability, increased anxiety, acne, lightheadedness, headaches, palpitations, stomach issues, nausea, fatigue, and insomnia. But not to worry, if


by Nutratech



Overall Grade


  • Contains herbs
  • Contains caffeine-eliminating ingredients
  • Helps calm anxiety
  • Improves sleep quality
  • Support adrenal health
  • Restores cognitive function
  • Refund policy


  • May cause side effects

Why we choose it

Nutratech’s Alprazium is fast-acting and all-natural. The ingredients help to boost your mood, and balance it out. But unfortunately, it’s got side effects similar to that of Mood Boost – stomach discomfort, increased anxiety, trouble sleeping, headaches, drowsiness, fatigue, lethargy, heart palpitations, chest tightness, shortness of breath, and chills. Some customers have also commented on the strong, unpleasant smell. Still, it’s got a 30-day refund policy. Despite the side effects, it still falls at #3 on our list

Anti Anxiety

by Prime Labs



Overall Grade


  • Chewable gummy supplements
  • Uses natural sweeteners
  • Boosts natural sleep hormone
  • Encourages a calm feeling
  • Supports healthy sleep cycle


  • Contains sugar (glucose syrup)
  • Bad/Overwhelming taste
  • May take awhile to work
  • Has tendency to melt when exposed to heat
  • May cause side effects

Why we choose it

Prime Labs’ Anti Anxiety contains all-natural ingredients. A highlight is the essential B-vitamins in these supplements that reduce anxiety and stress. Anti Anxiety also contains ingredients that boost serotonin – which is extremely important in anxiety treatment. But it’s got some harsh side effects…increased anxiety, irritability, insomnia, lethargy, fatigue, allergic reactions, breakouts, hives, stomach cramps, gas, and head & neck tension.

Anxiety Formula

by Optimal Effects



Overall Grade


  • Natural calming ingredients
  • Settles the mind and body
  • Promotes deep sleep
  • Gives a boost of natural energy
  • Supports sleep management
  • No groggy feeling
  • Lifetime guarantee


  • May take awhile to work
  • May cause side effects

Why we choose it

Optimal Effects Anxiety Formula is also all-natural, and this supplement allows a decrease in negativity and stress while promoting focus. Thankfully, it doesn’t cause drowsiness. Their side effects are pretty harsh, though. Customers report migraines, blurred vision, high blood pressure, and stomach discomfort. Luckily, Optimal Effects has a 60-day refund policy. They’ve landed at #5 on the list due to the severity of the side effects.

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